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Testosterone Treatment for Multiple Sclerosis
While many of the currently used pharmaceutical interventions in the treatment of multiple sclerosis (MS) are designed to reduce the risk of developing new brain lesions, precious little attention has been paid to exploring interventions that target two other consequences of this disease - impaired cognitive function and brain atrophy.
UCLA researchers recently published their work in the journal Archives of Neurology Arch Neurol in which they described treating men with MS with testosterone gel. Subjects received testosterone in the form of a topical gel providing 100mg of testosterone each day for 1 year. At the end of the study, the use of the testosterone gel was associated with an actual improvement in cognitive function and a dramatic slowing in the rate of brain atrophy.
Testosterone gel is widely available at compounding pharmacies around the country but should be used under the direction of a physician.
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September 5th, 2007 at 6:38 am
Dr. Perlmutter, are you using the testosterone gel in the treatment of your patients? Has there been any research done on the use of this therapy for females? Thanks!
September 5th, 2007 at 8:00 am
Dr. Perlmutter,
You cover quite an array of topics on this blog that are interesting. I’m raising some “Neurological-type” questions on my blog and would appreciate some alternative professional input — http://aiws-talk.blogspot.com — if you have time.
Thank you.
September 7th, 2007 at 4:33 am
We routinely use testosterone gels, creams and oral supplements with our female patients. I am not aware of any interventional trials using testosterone in women with MS.
September 10th, 2007 at 6:17 am
Just want to be sure I did not misunderstand — you said you routinely use the testosterone products with your FEMALE patients. Is that correct? I thought maybe you meant to say that you use the products in Male patients.
September 10th, 2007 at 6:19 am
Yes indeed. Giving testosterone to women is standard practice with physicians using bioidentical hormaone replacement protocols.