Raise a Smarter Child by Kindergarten
Raise a Smarter Child by Kindergarten
by David Perlmutter, MD, FACN, ABIHM
The Better Brain Book


by David Perlmutter, MD, FACN, ABIHM

Popular Herbicide Affects Sexual Development in Frogs, Research Finds

December 6th, 2009

From ScienceDaily.com:

The controversy surrounding the unintended effects of herbicide and pesticide use has intensified as researchers from the University of Ottawa’s Department of Biology have identified that atrazine, a heavily-used herbicide, alters the sexual development in frogs.

There have been numerous scientific and journalistic reports on the detrimental effects of herbicides, including atrazine, yet investigations by other research teams report no adverse effects of the popular herbicide.
In an attempt to help resolve differences between the various reports, Dr. Vance Trudeau and his team at the University of Ottawa’s Centre for Advanced Research in Environmental Genomics developed a system to evaluate the effects of a commercial formulation of atrazine. Specifically, PhD student Valérie Langlois applied it to outdoor tanks where tadpoles of leopard frogs were kept for an entire spring and summer. Under these semi-natural conditions in mesocosms, the levels of atrazine were low and comparable to those measured in the Canadian environment.
At the end of the summer, the results showed that atrazine levels in the tanks were at levels within currently acceptable guidelines. However, researchers also found that the herbicide reduced the number of tadpoles reaching the froglet stage. Also noteworthy was that atrazine had a feminizing effect on the animal, resulting in sex ratios favouring females, with a reduced number of males.
This study, recently available online in the journal Environmental Health Perspectives, raises important questions about the level of atrazine in the environment, and its negative effects on animal development.
Atrazine is one of the top selling herbicides used worldwide and was designed to inhibit weed growth in cornfields. It is so widely used that it can be detected in many rivers, streams and in some water supplies. This has raised the alarm on the possibility of other serious detrimental environmental effects

Lead, Tobacco Exposure Linked to ADHD

November 25th, 2009

Health Risks Seen in Prenatal Tobacco Smoke Exposure and Childhood Lead Exposure

From WebMD.com:

Prenatal exposure to tobacco smoke and childhood exposure to lead are linked to increased risk of attention deficit hyperactivity disorder ( ADHD) in children, a new study shows.

The study is published in the December issue of Pediatrics.

Researchers led by Tanya E. Froehlich, MD, MS, of the department of pediatrics at Cincinnati Children’s Hospital Medical Center, analyzed data of prenatal tobacco and childhood lead exposure in the 2001-2004 National Health and Nutrition Examination Survey, a representative sample of U.S. children aged 8 to 15.

Prenatal tobacco exposure was measured by reports of cigarette use during pregnancy, and childhood lead exposure was assessed by blood levels.

The researchers say they found that young people exposed prenatally to tobacco smoke were 2.4 times more likely to have ADHD, and that those with blood levels in the top third of the population had a 2.3-fold increased likelihood of ADHD diagnosis.

The combined effect from both toxicants was even greater. Children with both exposures had a more than eightfold increased chance of having ADHD, compared to youths who weren’t exposed to either, the researchers say.

The authors say their study is the first to determine the independent effects of tobacco smoke and lead on ADHD in a nationally representative sample, and contend it provides the first estimate of joint effects of the two common toxicants.

The researchers examined data on 2,588 youngsters from the National Health and Nutrition Examination Survey 2001-2004 and 8.7% met criteria for diagnosis with ADHD. “Our findings suggest that reduction of toxicant exposures may be an important avenue for ADHD prevention and they underscore the enormous burden that may be associated with continued exposure to tobacco and lead,” the researchers conclude.

Regulators Plan to Study Risks of Atrazine

October 25th, 2009

From NYTimes.com:

The Environmental Protection Agency plans to conduct a new study about the potential health risks of atrazine, a widely used weedkiller that recent research suggests may be more dangerous to humans than previously thought.

Atrazine — a herbicide often used on corn fields, golf courses and even lawns — has become one of the most common contaminants in American drinking water.

For years, the E.P.A. has decided against acting on calls to ban the chemical from environmental activists and some scientists who argued that runoff was polluting ecosystems and harming animals.

More recently, new studies have suggested that atrazine in drinking water is associated with birth defects, low birth weights and reproductive problems among humans, even at concentrations that meet current federal standards.

The E.P.A. is expected to announce on Wednesday that it will conduct a new evaluation of the pesticide to assess any possible links between atrazine and cancer, as well as other health problems, such as premature births. The E.P.A. may determine that new restrictions are necessary.

The decision by E.P.A.’s administrator, Lisa P. Jackson, who took over the agency in January, is a significant departure from the policies of the E.P.A. under President George W. Bush.

For years, agency officials said that atrazine in drinking water posed almost no risk to humans or the environment. As recently as this summer, E.P.A. staff members argued that current regulations were adequate.

“We’re going to use our scientific resources in a new and more aggressive way regarding atrazine,” said Stephen A. Owens, who was recently confirmed as E.P.A. assistant administrator for prevention, pesticides and toxic substances.

“There are new scientific findings that deserve attention, and we’re going to engage our scientific panels in actively reviewing the work of this office under previous administrations,” he added. “We have a question: Did the decisions made in previous administrations use all the available science?”

A representative of atrazine’s largest manufacturer, the Swiss company Syngenta, said that she had not been fully briefed on the E.P.A.’s announcement. However, the spokeswoman, Sherry Ford, said, “we expect a positive outcome for atrazine at the end of this process.”

Ms. Ford added that the company “stands behind the safety of atrazine, which has undergone extensive testing. We are a science-based company, and we expect the E.P.A. to make sound decisions based on science, no matter which administration is currently in power.”

Observers say the E.P.A.’s announcement signals a significant shift.

“This is a dramatic change,” said Linda Birnbaum, director of the National Institute of Environmental Health Sciences, part of the Department of Health and Human Services. “There is growing evidence that atrazine could be a hazard to human health. This is a strong signal that the world is changing for some of the most widely used chemicals.”

Atrazine has become a lightning rod in disputes over how the E.P.A. has used scientific findings to regulate chemicals and toxins.

The agency was sued in 2003 by an environmental advocacy organization, the Natural Resources Defense Council, amid claims that regulators had ignored studies showing that atrazine was dangerous to some animals.

In August, The New York Times reported on recent epidemiological studies that suggested small amounts of atrazine in drinking water, including levels considered safe by federal standards, might be associated with birth defects — including skull and facial malformations and misshapen limbs — as well as premature births and low birth weights in newborns.

E.P.A. officials said those studies, as well as recent papers reviewing numerous studies that showed that atrazine interferes with the development and hormone systems of some animals, played a role in their decision to re-evaluate the chemical.

A Times analysis of E.P.A. records also found that in some American towns, atrazine concentrations in drinking water had spiked sharply, sometimes for as long as a month. Though the E.P.A. and Syngenta were aware of those spikes, they often did not promptly warn local water systems, and the reports produced by local regulators and distributed to residents often failed to reflect those higher concentrations. Interviews with local water officials indicated that many of them were unaware that atrazine concentrations sometimes jumped sharply in their communities.

But officials in other communities have grown concerned. Water systems in six states — Illinois, Indiana, Iowa, Kansas, Mississippi and Ohio — recently sued atrazine’s manufacturers to force them to pay for removing the chemical from drinking water.

The E.P.A. is expected to announce on Wednesday four meetings over the coming year of the agency’s independent scientific advisory panel that will focus on atrazine.

Increased Risk Of Birth Defects After PCE Exposure

October 5th, 2009

Why drink bottled water

From ScienceDaily.com

Exposure to tetrachloroethylene (also known as perchlorethylene, PCE) may cause congenital birth defects. A study of expectant women exposed to PCE in drinking water, published in BioMed Central’s open access journal Environmental Health, found an increased risk of oral clefts and neural tube defects in their children.

Ann Aschengrau, from Boston University School of Public Health, USA, worked with a team of researchers to study the prevalence of birth defects in the children of women from 8 towns in Cape Cod who had been exposed to PCE during the period 1969-1983. She said, “The results suggest that the risk of certain congenital anomalies is increased among the offspring of women who were exposed to PCE-contaminated drinking water around the time of conception”.

From the late 1960s until 1980, hundreds of miles of pipe that had been lined with a vinyl coating containing PCE were laid in the area. It wasn’t until 1980 that officials realized the danger, creating what the researchers describe as “A vast natural experiment reminiscent of John Snow’s cholera investigation in 1854 London.” Boston University investigators found that there were 61 children with congenital anomalies among the 1,658 children with some prenatal PCE exposure and 95 children with congenital anomalies among 2,999 children with no prenatal PCE exposure. Prenatal exposure was associated with increases in the risk of oral clefts and neural tube defects (particularly anencephaly).

Speaking about these findings, Aschengrau said, “Because PCE remains a commonly used solvent and frequent contaminant of ground and drinking water supplies, it is important to understand its impact on the developing fetus.”

Concerns about Bisphenol A and How You Can Protect Yourself

September 21st, 2009

Bisphenol A (BPA) is a chemical currently used to manufacture hard, light-weight plastic water bottles that have #7 recycle designation or “PC” for polycarbonate on the bottom. BPA is also used in baby bottles, as well as epoxy linings of metal food cans, including canned infant formula. Nearly six billion pounds of BPA is produced annually. The BPA molecules link to form polymers which are unstable, break-off, and allow the BPA to leach into the water and food that comes in contact with the plastic. New research indicates that BPA acts like a synthetic estrogen, also called a xenoestrogen (external, non-human made estrogen) that acts as an endocrine disrupting chemical (1).

For a long-time the plastics manufacturers have assured the government and the public that BPA is safe. However, studies conducted over the past 20 years now show it’s not only an ubiquitous pollutant in the human body, contaminating nearly 93% of the population, but also a potent developmental toxin at very low doses (2). The Environmental Working Group (EWG) has put together a timeline about BPA. Here are the highlights:
1891: BPA discovered.
1930s: First evidence of toxicity. The chemical industry begins to use BPA to manufacture a hard plastic called polycarbonate, and to make epoxy resins used as linings for metal food cans and a variety of other products. Although BPA leaches out of plastic long after its manufacture, the material is used in consumer products with no requirement that companies prove it is safe.
1976: First law to regulate industrial chemicals fails to establish safety for BPA which is one of 62,000 chemicals “grandfathered” in and presumed safe by the Environmental Protection Agency.
Late 1980s through 1990s: First BPA safety standard at odds with first low-dose BPA studies.
2003-2006: First serious government evaluation of BPA low-dose toxicity led by industry consultant.
2007: Industry influence on BPA science is revealed. Agency fires contractor. Government panel ignores low-dose BPA toxicity in favor of industry studies, BPA experts warn of health risks.
Late 2007-Early 2008: FDA and infant formula manufacturers’ positions on safety of BPA for babies come under fire, Congress investigates.
2008: Government finds BPA poses risks to humans, Wal-Mart and other retailers pull BPA products from shelves. Industry fights California effort to ban BPA from kids products. FDA poised to ignore dozens of laboratory studies and declare BPA exposures to baby “safe”. 2009: Over 20 states introduce bills to reduce children’s exposure to BPA. Is 2009 the year of action? (2)
Here are three research studies that validate three key steps in understanding the concerns about BPA. First research tested the hypothesis that “bioactive BPA was released from polycarbonate bottles used for consumption of water and other beverages. . .[and] evaluated whether BPA migrated into water stored in new or used high-quality polycarbonate bottles used by consumers. . . .BPA was found to migrate from polycarbonate water bottles at rates ranging from 0.20 nanograms/hour to 0.79 nanogram/hour. At room temperature the migration of BPA was independent of whether or not the bottle had been previously used. Exposure to boiling water (100 °C) increased the rate of BPA migration by up to 55-fold” (3).
Second, BPA enters the body & is excreted by kidneys. A study published in 2009 involving 77 Harvard College students “examined the association between the use of polycarbonate beverage containers for one week and urinary BPA concentrations.” The authors concluded, “One week of polycarbonate bottles use increased urinary BPA concentrations by 69%. Regular consumption of cold beverages from polycarbonate bottles is associated with a substantial increase in urinary BPA concentrations irrespective of exposure to BPA from other sources”(4).

BPA has significant affects on non-human primates. Researchers . . . examined the influence of continuous BPA administration, at a daily dose equal to the current U.S. Environmental Protection Agency’s reference safe daily limit, on estradiol-induced spine synapse formation in the hippocampus and prefrontal cortex of a nonhuman primate [monkey] model. Our data indicate that even at this relatively low exposure level, BPA completely abolishes the synaptogenic response to estradiol. Because remodeling of spine synapses may play a critical role in cognition and mood, the ability of BPA to interfere with spine synapse formation has profound implications. This study is the first to demonstrate an adverse effect of BPA on the brain in a nonhuman primate model and further amplifies concerns about the widespread use of BPA in medical equipment, and in food preparation and storage (5).

For more information refer to the review article by Vandenberg et.al. (6) and the list of 525 articles (7).

Do you carry a plastic water bottle, either clear or colored? Check the bottom. Do you find a triangular recycle logo with the number “7” in the center and/or the letters “PC”? If so, that bottle contains BPA. To reduce your exposure:
* Avoid bottles and plastic containers that are made from polycarbonate.
* Carry water in stainless steel bottles
* Eat less canned food and more frozen or fresh food.
* Breastfeed your baby or use powdered formula instead of cans.
* Download “EWG’s Guide to Infant Formula and Baby Bottles: Guide to Baby-Safe
Bottles & Formula” and share it with someone you know who is pregnant or has a small infant (8).

References:
1. Hoffman, Matthew, “Pots, Pans, and Plastics: A Shopper’s Guide to Food Safety”, Web MD, March 6, 2009
2. Houlihan, J. et.al. “Timeline: From Invention to Phase-Out”, April 2008

3. Hoa HL et.al. “Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons”, 2008; 176(2):149-156
4. Carwile, JL, et. al. “Polycarbonate Bottle Use and Urinary Bisphenol A Concentrations”, 2009; Environmental Health Perspectives; 117(9)
5. Csaba, Leranth et.al. “Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates”, 2008; Proceedings of the National Academy of Sciences; 105(37): 14187-14191.
6. Vandenberg, LN, et. al. “Human exposure to bisphenol A (BPA)” 2007; Reproductive Toxicology;24(2):139-77.
7. References and abstracts for 525 articles about BPA
8. “EWG’s Guide to Infant Formula and Baby Bottles: Guide to Baby-Safe Bottles & Formula”