Subscribe

Renegade
Neurologist
RSS Feed

Search

Wellness Health
Visit Our Sponsor »

Archive for the 'Depression' Category

Antidepressant Use Tied to Poorer Driving

But experts aren’t sure if the pills, or underlying depression, are to blame

From healthday.com
Taking prescription antidepressants while still highly depressed could impair driving ability, a new study suggests.

“We already know that depression causes concentration problems,” said study author Holly J. Dannewitz. “And now it appears that people taking antidepressants who also have relatively higher depression scores fare significantly worse when attempting to perform a computerized simulation of driving.”

Dannewitz conducted her research while a graduate student at the University of North Dakota in Grand Forks, where she is currently a psychology resident in a private practice.

She and her colleagues were scheduled to present their findings Sunday the American Psychological Association annual meeting, in Boston.

To gauge the possible impact antidepressants might have on driving performance, the research team asked 60 people to “drive” a computerized version of a car in a program that mimicked real-world conditions.

Approximately half of the participants were taking at least one type of antidepressant, while the other half was taking no medication (other than oral contraceptives in certain instances). Those on antidepressants were screened for current levels of depression and were subsequently categorized as experiencing either low or high depression at the time of the driving test.

Participants had to perform common driving tasks such as braking, steering, and scanning sightlines in response to an unfolding video of car traffic, stop signs, speed limit signs, traffic lights, deer crossings, bicyclists, and even the appearance of helicopters.

People taking antidepressants who were highly depressed registered markedly worse scores on some driving skills than those not taking antidepressants, the team found. This appeared tied to poorer concentration and a weakened ability to react well to situations that divided their attention and relied on memory skills.

These deficits weren’t found among those who were taking antidepressants but had low depression scores. In fact, that group was found to execute their driving tasks with a precision equal to that of those not on medication.

Dannewitz said that her future work would involve patients who are diagnosed with clinical depression but not on antidepressants. In this way, her team can determine whether it’s the depression, or medications used to treat it, that are at the root of the concentration problems.

“More research needs to be done, of course,” she said. “And I wouldn’t want to instill fear in drivers. But I think that perhaps individuals who are taking these medications should just be aware of the fact that they may cause concentration problems and impair reaction time.”

Dannewitz also stressed that, “this issue is not just a question for drivers, because the cognitive skills needed for driving are also needed for a lot of other skills.”

Dr. Bernard Carroll, scientific director of the Pacific Behavioral Research Foundation based in Carmel, California, agreed that it’s too early to draw specific conclusions from the study. But he said the findings weren’t surprising.

“There is already a very deep literature about subtle impairments of higher cognitive function associated with clinical depression itself, apart from medications,” he noted. “I would add that, in any case, medication package inserts routinely warn patients about a whole host of issues when starting a course of psychotropic drugs, including warning against the handling of machinery, driving, or engaging in any occupation in which you can be injured. So, to that extent, this concern isn’t new.”

Share this Article:

Mailing List:


Low vitamin D boosts depression risk in seniors

From News - Revolution Health

Older people with low blood levels of vitamin D and high blood levels of parathyroid hormone are more likely to be depressed, Dutch researchers report.

But it remains unclear whether these abnormalities are a cause or a consequence of depression, Dr. Witte J. G. Hoogendijk and colleagues from Vrije Universiteit in Amsterdam say.

Past studies have linked altered levels of vitamin D and parathyroid hormone with depression, but the relationship “has never been studied systematically,” Hoogendijk and colleagues note. To investigate, they looked at 1,282 men and women aged 65 to 95 years participating in a long-term study of aging.

Nearly 40 percent of the men and 57 percent of women had low levels of vitamin D in their blood.

Among the 169 people found by self-report and diagnostic interviews to be suffering from minor depression, as well as the 26 with major depressive disorder, vitamin D levels were 14 percent lower than for people who were free from depression, the researchers found.

And blood levels of parathyroid hormone, which increase with vitamin D deficiency, were 5 percent higher in people with minor depression and 33 percent higher in those with major depression, relative to levels seen in seniors without depression.

There are a number of plausible ways that low vitamin D levels could influence mood, the researchers note, given that the vitamin plays a role in several neurological and hormonal processes.

If vitamin D deficiency is a cause rather than a result of depression, they add, this suggests supplementation with the vitamin and increased exposure to sunlight could help treat the mood disorder.

Long-term studies with repeated assessments are needed to explore the question of whether decreased vitamin D levels and increased parathyroid hormone levels precede depression or follow it, the researchers conclude.

Share this Article:

Mailing List:


Relatives of Parkinson’s Patients at Higher Psychiatric Risk

This suggests a link between the illness and depression, anxiety disorders, researchers say

From HealthScout

The close relatives of people with Parkinson’s disease are at increased risk for depression and anxiety disorders, new research suggests.

The risk is particularly high in the brothers, sisters, parents and children of people who develop Parkinson’s before age 75, said a team from the Mayo Clinic in Rochester, Minn.

The study included 1,000 immediate relatives of 162 Parkinson’s patients and 850 immediate relatives of 147 people without Parkinson’s. It’s the first large population-based study to identify this kind of association.

“Studies by our group and others have shown that relatives of patients with Parkinson’s disease have an increased risk of Parkinson’s disease. Recently, we showed they also have increased risk of essential tremor and of cognitive impairment or dementia. However, the risk of psychiatric disorders was unknown,” senior author Dr. Walter Rocca, a neurologist and epidemiologist, said in a prepared statement.

“Because many patients with Parkinson’s disease develop anxiety and depression after and even before the onset of the disease, we explored whether this tendency was present to a greater extent in family members of people with Parkinson’s disease compared with people without the disease. We found that, indeed, relatives of patients with Parkinson’s disease are at increased risk for anxiety and depressive disorders, which suggests a genetic or other relationship between those disorders and Parkinson’s disease,” Rocca said.

Further research is needed to determine the exact cause or causes that boost the risk, he said.

The study was published in the December issue of the journal Archives of General Psychiatry.

Share this Article:

Mailing List:


Blood Pressure Drug May Curb Brain Damage From Alzheimer’s, Depression And Schizophrenia

From Sciencedaily.com

A drug used to treat high blood pressure and enlargement of the prostate may protect the brain from damage caused by post-traumatic stress disorder, Alzheimer’s disease, depression and schizophrenia.

Prazosin, also prescribed as an antipsychotic medication, appears to block the increase of steroid hormones known as glucocorticoids, Oregon Health & Science University and Portland Veterans Affairs Medical Center researchers have found. Elevated levels of glucocorticoids are associated with atrophy in nerve branches where impulses are transmitted, and even nerve cell death, in the hippocampus.

The hippocampus is the elongated ridge located in the cerebral cortex of the brain where emotions and memory are processed.

“It’s known, from human studies, that corticosteroids are not good for you cognitively,” said study co-author S. Paul Berger, M.D., assistant professor of psychiatry and behavioral neuroscience, OHSU School of Medicine and the PVAMC. “We think prazosin protects the brain from being damaged by excessive levels of corticosteroid stress hormones.”

The study, titled “Prazosin attenuates dexamethasone-induced HSP70 expression in the cortex,” is being presented during a poster session today at Neuroscience 2007, the annual Society for Neuroscience conference in San Diego.

Scientists believe stress activates a neurochemical response in the brain that triggers the release of glucocorticoids in the brain, and that high levels of glucocorticoids in blood serum are associated with such psychiatric conditions as schizophrenia, depression, PTSD and Alzheimer’s disease. This mechanism has been linked to decreases in cognitive performance in older people who are not suffering from clinical dementia.

“Our hypothesis is that just being afraid of being blown up all the time means you have high levels of steroids all the time,” Berger said, referring to PTSD among military personnel.

Low levels of glucocorticoids have anti-inflammatory effects in the brain, but high levels can trigger inflammatory mechanisms that damage nerve cells by activating an enzyme that causes oxidative stress. Even a single exposure to a high dose of glucocorticoids can be sufficient to damage nerve cells: A previous study showed synthetic glucocorticoid therapy to treat autoimmune disorders such as rheumatoid arthritis can induce mood disorders, including psychosis, and cognitive impairment known as “steroid dementia” in severe forms.

To determine the effects of prazosin, OHSU and PVAMC researchers, led by Altaf Darvesh, Ph.D., formerly of the OHSU Department of Psychiatry, administered a glucocorticoid called dexamethasone to rats, then measured the expression of a protein known as heat shock protein 70, or HSP70, that serves as a marker for neurotoxicity. Pretreatment with prazosin, an alpha-1 receptor antagonist, resulted in “significant” slowing of dexamethasone-induced expression in the cerebral cortex.

“The one thing we don’t know for sure is, would you have to get it before you’re traumatized,” Berger said. “Lots of people have high levels of corticosteroids when they’re under stress, so could we give them prazosin ahead of time to protect them from brain damage?”

Berger said future research will continue to look at where and how steroids cause brain damage, and just when prazosin would have to be administered to most effectively protect the brain against damage.

“We just looked at brain damage,” he said. “Steroids are known to cause cognitive impairment in both rats and people, so the next step is to see if we can correlate brain damage with cognitive effects and determine if we can protect against brain damage to protect cognition.”

Share this Article:

Mailing List:


Why I Treat Depression with Omega 3 Supplements

Read entire citation here:Omega-3 fatty acids and major depression: A primer for the mental health professional

Abstract

Omega-3 fatty acids play a critical role in the development and function of the central nervous system. Emerging research is establishing an association between omega-3 fatty acids (alpha-linolenic, eicosapentaenoic, docosahexaenoic) and major depressive disorder. Evidence from epidemiological, laboratory and clinical studies suggest that dietary lipids and other associated nutritional factors may influence vulnerability and outcome in depressive disorders. Research in this area is growing at a rapid pace. The goal of this report is to integrate various branches of research in order to update mental health professionals.

Share this Article:

Mailing List: