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Archive for November, 2008

Exercise Keeps the Brain Young

Experiments in mice find running increases production of neural stem cells

From healthday.com
In experiments in mice, exercise appears to reverse the decline in the production of brain stem cells usually seen with aging, Taiwanese researchers report.

This remarkable restoration of the brain’s ability to stave off aging appears to be due to exercise’s ability to restore a neurochemical that is essential for the production of new brain cells.

“As we age, the ability of producing new neurons is decreasing. However, moderate running can improve the production, survival and maturation of new neurons in the brain,” said lead researcher Yu-Min Kuo, an associate professor in the Department of Cell Biology and Anatomy at the National Cheng Kung University Medical College in Tainan. “The younger one starts to run, the better.”

The report is published in the November issue of the Journal of Applied Physiology.

For the study, Kuo’s team trained young, adult, middle-aged and old mice to run on a treadmill for up to an hour a day. The researchers then looked at the ability of the brain to continue to produce neural cells.

In middle-aged mice, the number of neural progenitor and mitotic cells in the hippocampus, a brain region intimately associated with learning and memory, decreased dramatically, Kuo explained.

“Compared to the sedentary middle-aged mice, moderate treadmill running not only doubled the production of neural stem cells but also enhanced the survival and growth of the newborn neurons,” Kuo said. “Running had a more pronounced effect on younger animals than older counterparts.”

The researchers found that this phenomenon could not be explained by an increase in a hormone called corticosterone, as they had speculated.

Rather, moderate running increased the concentrations of brain-derived neuron growth factor and its receptor, TrkB, in the hippocampus, while the level of corticosterone in mice stayed constant, Kuo said.

“The production of neural stem cells in the hippocampus decreases dramatically by middle age, and moderate running exercise can slow this trend,” Kuo said. “Chronic moderate running enhances the production of neurotrophic factor, which promotes neurogenesis, and the differentiation and survival of newborn neurons.”

Paul Sanberg, director of the University of South Florida Center for Aging and Brain Repair, concurs that exercise could promote the growth of new brain stem cells in people.

“This provides more understanding of its potential in humans,” Sanberg said. “That there is a significant effect in middle-aged animals suggests that in middle-aged people that this would also occur.”

There needs to be more data in humans to see if the growth of new brain cells has an effect on cognitive ability, Sanberg noted. “But it’s encouraging the continued use of exercise to maintain health and proper health of our brain,” he said.

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Web Health Searches Often Result in ‘Cyberchondria’

From healthday.com
People who use the Internet to self-diagnosis health problems often mistakenly end up thinking they have a rare illness, according to Microsoft researchers who analyzed Web search results and surveyed 515 people about their online health information search experiences.

“Common, likely innocuous symptoms can escalate into the review of content on serious, rare conditions that are linked to the common symptoms,” said study authors Ryen White and Eric Horvitz, Agence France Presse reported.

An example of “cyberchondria” is someone with a headache who concludes it’s a sign of a brain tumor.

“A brain tumor is a concerning possibility when a searcher experiences headache. However, the probability of a brain tumor given a general complaint of headache is typically quite low,” the researchers said, AFP reported.

“Such escalations from common symptoms to serious concerns may lead to unnecessary anxiety, investment of time, and expensive engagements with healthcare professionals,” they added.

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New “Fat Burning” Compound Mimics Natural Substance

From healthnews.com
Scientists have long been on the search for a new fat-burning medication and it looks like they have found a new candidate that could help keep extra weight off, even on a high-fat diet. The new medication, which is in development, mimics a health-boosting compound that is found in red wine and may prove to be a powerful weapon in the fight against diabetes and obesity.

A new study conducted on mice showed that GlaxoSmithKline drug SRT1720 was approximately 1,000 times more potent than resveratrol in activating an enzyme that helped the mice burn more energy and lower their glucose and insulin levels. So far, this experimental drug has only been tested on mice, but when the mice got a high daily dose of the drug for around three months, they didn’t even gain weight on a diet that was high in fat. However, a lower dose of the drug was not as effective.

The researchers reported that the mice that were fed a high-fat diet were tricked into switching their metabolisms to a fat-burning mode that would normally take over when their energy levels are low.

Peter Elliot, the vice president at Sirtris Pharmaceuticals (the Glaxo unit that developed the medication), said, “We are activating the same enzymes that are activated when people go to the gym. That is why we believe the profile for this drug is very safe.” When the mice were given the high dose of the drug they gained strength and endurance, and did not develop insulin resistance, which is a condition that precedes type 2 diabetes.

Resveratrol is found in large amounts in red wine and grapes and is believed to provide numerous heath benefits, including the prevention of heart disease. A previous study from the same team showed that it lowered insulin and glucose in diabetics. The incident of cancer and heart disease among the population that consumes a great deal of red wine is dramatically less than those that don’t, even if they may also have a diet that is high in fat. Resveratrol has been demonstrated to promote the formation of new dendrites in the brain. Resveratrol and the other bioflavoniods and polyphenols are present in large amounts in bark of grape vines, twigs, and leaves. In turn, red wine, which is fermented with the skins of the grapes, twigs and seeds, etc., tends to contain a much larger amount of the beneficial substances than white wine which is fermented only from the pressed juice of the grape.

The natural compound has also drawn much interest from some companies and scientists, including GlaxoSmithKline, which this year paid approximately $720 million dollars for Sirtris in a deal that allowed them to acquire a number of developmental medications for a range of diseases.

A Phase I trail conducted has shown that the treatment is safe and very well-tolerated and the company is planning on beginning a wider Phase II trail with patients with diabetes in 2009, according to Elliot, who led the study.

Resveratrol has been shown to make mice live a longer life and stay healthier. In the researcher’s study of mice that were diabetic, they found that the experimental medication helped lower their insulin and blood sugar levels to normal levels within just a few weeks with no harmful side effects.

It has also been shown to lower cholesterol and helped the mice on the medication lose a modest amount of weight compared to the mice that were given a placebo, Elliot stated. The mice that were on the medication were also able to exercise twice as long.

SRT1720 is still a long way from being ready to use in people, but there is already a low-tech way of preventing weight gain and also benefiting the bones, heart and the rest of the body. This is the timeless combination of an active lifestyle and a healthy diet.

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Common Sense Approach to Pests

By David Perlmutter, MD, FACN, ABIHM

Pesticides are one of the most common–and potentially dangerous- hazards in the home. There are an estimated 1,400 pesticides in consumer products as part of the ingredients. Of the 1,400 pesticides, at least 37 registered for use on foods are neurotoxic organophosphate insecticides. These substances are closely related chemically to even more toxic nerve agents used in conducting warfare that were developed at the beginning of the 20th century.
What’s particularly alarming is the fact that pound for pound, children eat more fruits and vegetables, in relation to their body weight, than adults do. As such, some 20 million American children, ages five and under, eat an average of eight pesticides every day through their food. This is one of the reasons I believe that organic produce is well worth the extra cost. Pesticides are especially dangerous to children because the residue is stored in fat cells and remain in the body indefinitely. Therefore, the younger the exposure, the more lethal and toxic the buildup.
Organophosphates are the class of pesticide widely used that are particularly toxic to the developing brain. They are in a class of toxic organic molecules containing phosphate, and often fluoride, that are used in both insecticides and nerve gases (such as sarin). Many of these molecules block the action of an enzyme (acetylcholinesterase) that recycles an important brain chemical called acetylcholine. Acetylcholine is a neurotransmitter that controls the actions of skeletal and smooth muscle in the peripheral nervous system, and that may also regulate memory (it is severely diminished in the brains of people with Alzheimer’s disease). Because the enzyme is inhibited, acetylcholine builds up in the system, causing nervous system dysfunction.
The substances many people use to control pests at home, especially in the lawn or garden, are also the organophosphates. When there is acute exposure (high levels all at once), they have been shown in some cases to cause permanent damage of the workings of the brain. Some behavioral effects have been seen even when the exposure is brief, or at a low level. Studies on newly born mice showed that a single dose of an organophosphate 10 days after birth– a stage that is similar to the stage in humans during the last trimester of pregnancy– linked to hyperactivity in the same mice at four months of age. In a comparative study in Mexico, children exposed to pesticides in the 1960s and 70s demonstrated decreases in stamina, coordination, memory, and the ability to draw familiar subjects.
Other organophosphates include chlorpyrifos (Dursban) and diazinon, both of which are linked to neurochemical and behavioral changes in lab animals. In the late 1990s, after it had been used in homes and schools for the previous 30 years, the EPA and Dow AgroSciences agreed to phase-out chlorpyrifos (Dursban), one of the most commonly used insecticides in schools, because of its high risks to children.
I live in a warm humid climate and we are endlessly challenged by insects and pests in and out of our home. We have never used toxic pesticides around our home or outdoors and never will. There are natural and safer alternatives that can help control pests and weeds without putting the health of your family at risk.
A Safer Bug Repellent. Many commercial bug repellents contain DEET (diethyl-m-toluamide) which is a neurotoxin. No doubt it works well at repelling insects but I fear the long term side effects. I recommend using a natural herbal based bug repellent such as Bug Off, (which contains, among other ingredients, lemon eucalptus oil and karanja oil,) Bite Blocker, a soy based bug repellent or Burt’s Bees Herbal Insect Repellent. Children under 3 should not use any bug repellent product because they are likely to rub their eyes or put their hands in the mouth. Instead, put a screen over their stroller to keep bugs out the old fashioned way.
If your children go outdoors in areas that are infested with mosquitos or ticks, be sure that they are wearing long sleeves and long pants that are tucked into their socks. I know that kids like to wear shorts in the warm weather, but if they are playing in wooded areas they still need to wear lightweight clothing that covers their bodies.
Keep Pests out the Natural Way Take steps to make your home, and especially your kitchen, an inhospitable place for pests. For example, when possible, clean up food spills immediately, keep all areas as clean as possible, especially the hard-to-reach areas where pests can hide. Pests can also hide in clutter, so try to remove as much as you can. Keep food that attracts pests in the refrigerator, including flour. Remember that water attracts pests, so have any leaks repaired immediately. Keep screens on doors and windows, and clean and air your clothes regularly. Store the clothes that are out of season in airtight containers to prevent moth infestation.
Control Indoor Insects You can make insect repellent with foods that attract insects mixed with food that is poisonous to them, but non-toxic for you. For example, mix equal parts of oatmeal and plaster-of-Paris or equal parts of powder and flour with borax. Sprinkle these mixtures directly on the areas where you have seen insects and on the doorways where insects gain entry in your home. Or try using old-fashioned flypaper. Although these mixtures are non toxic, they can still make you sick, so don’t allow them to come in contact with food. And clean up the exposed areas before allowing your child to crawl on the floor.
And remember, some of these toxic chemicals can stay around for decades, which means even if you are scrupulous about not using neurotoxic chemicals, you can’t be sure what the past owners did. If you suspect that your backyard has ever been treated with pesticides, I don’t recommend allowing small children to crawl around the yard because their faces are literally in the dirt. It’s fine for older children to play outdoors, but make sure they wash their hands and face very well when they come into the house.

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Aquarobics May Help Ease Labor

Women who exercised during pregnancy needed less pain meds, study found

From healthday.com
Doing aquarobics during pregnancy reduces the amount of pain-killing medication requested by women during labor, according to a Brazilian study that included 71 expectant mothers.

Half the women were assigned to attend three 50-minute sessions a week of aquarobics during their pregnancy, while the other half acted as a control group.

“We found no statistically significant differences in the duration of labor or they type of delivery between the two groups,” study author Rosa Pereira, of the University of Campinas in Sao Paulo, said in a news release. “However, only 27 percent of women in the aquarobics group requested analgesia, compared to 65 percent in the control group. This represents a 58 percent reduction in requests.”

There’s some debate about the wisdom of women exercising during pregnancy. The main concern is that exercise may interfere with fetal/placental demands and compromise fetal development or growth or increase the risk of abnormalities. Pereira and colleagues concluded that aquarobics had no harmful effect on the cardiovascular health of pregnant women and also confirmed the well-being of infants born to the mothers who did aquarobics.

“We’ve shown that the regular practice of moderate water aerobics during pregnancy is not detrimental to the health of the mother or the child. In fact, the reduction in analgesia requests suggests that it can get women into better psycho-physical condition,” Pereira said.

The study was published in the journal Reproductive Health.

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